1la6

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{{STRUCTURE_1la6| PDB=1la6 | SCENE= }}
{{STRUCTURE_1la6| PDB=1la6 | SCENE= }}
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'''The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state'''
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===The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state===
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==Overview==
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Tetrameric hemoglobins are the most widely used systems in studying protein cooperativity. Allosteric effects in hemoglobins arise from the switch between a relaxed (R) state and a tense (T) state occurring upon oxygen release. Here we report the 2.0-A crystal structure of the main hemoglobin component of the Antarctic fish Trematomus newnesi, in a partial hemichrome form. The two alpha-subunit iron atoms are bound to a CO molecule, whereas in the beta subunits the distal histidine residue is the sixth ligand of the heme iron. This structure, a tetrameric hemoglobin in the hemichrome state, demonstrates that the iron coordination by the distal histidine, usually associated with denaturing states, may be tolerated in a native-like hemoglobin structure. In addition, several features of the tertiary and quaternary organization of this structure are intermediate between the R and T states and agree well with the R --&gt; T transition state properties obtained by spectroscopic and kinetic techniques. The analysis of this structure provides a detailed pathway of heme-heme communication and it indicates that the plasticity of the beta heme pocket plays a role in the R --&gt; T transition of tetrameric hemoglobins.
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(as it appears on PubMed at http://www.pubmed.gov), where 12093902 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12093902}}
==About this Structure==
==About this Structure==
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[[Category: Bishistidine complex]]
[[Category: Bishistidine complex]]
[[Category: Hemichrome]]
[[Category: Hemichrome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:43:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:05:59 2008''

Revision as of 09:06, 2 July 2008

Image:1la6.png

Template:STRUCTURE 1la6

The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state

Template:ABSTRACT PUBMED 12093902

About this Structure

1LA6 is a Protein complex structure of sequences from Trematomus newnesi. Full crystallographic information is available from OCA.

Reference

The crystal structure of a tetrameric hemoglobin in a partial hemichrome state., Riccio A, Vitagliano L, di Prisco G, Zagari A, Mazzarella L, Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9801-6. Epub 2002 Jul 1. PMID:12093902

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