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1r3g
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1r3g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R3G FirstGlance]. <br> | <table><tr><td colspan='2'>[[1r3g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R3G FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GMU:2-O-[(2-GUANIDINIUM)ETHYL]-5-METHYLURIDINE+5-MONOPHOSPHATE'>GMU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.16Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GMU:2-O-[(2-GUANIDINIUM)ETHYL]-5-METHYLURIDINE+5-MONOPHOSPHATE'>GMU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r3g OCA], [https://pdbe.org/1r3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r3g RCSB], [https://www.ebi.ac.uk/pdbsum/1r3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r3g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r3g OCA], [https://pdbe.org/1r3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r3g RCSB], [https://www.ebi.ac.uk/pdbsum/1r3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r3g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | [structure: see text] Oligonucleotides with a novel 2'-O-[2-(guanidinium)ethyl] (2'-O-GE) modification have been synthesized using a novel protecting group strategy for the guanidinium group. This modification enhances the binding affinity of oligonucleotides to RNA as well as duplex DNA (DeltaT(m) 3.2 degrees C per modification). The 2'-O-GE modified oligonucleotides exhibited exceptional resistance to nuclease degradation. The crystal structure of a palindromic duplex formed by a DNA oligonucleotide with a single 2'-O-GE modification was solved at 1.16 A resolution. | ||
| - | |||
| - | 2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures.,Prakash TP, Puschl A, Lesnik E, Mohan V, Tereshko V, Egli M, Manoharan M Org Lett. 2004 Jun 10;6(12):1971-4. PMID:15176796<ref>PMID:15176796</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1r3g" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
1.16A X-ray structure of the synthetic DNA fragment with the incorporated 2'-O-[(2-Guanidinium)ethyl]-5-methyluridine residues
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Categories: Large Structures | Egli M | Lesnik E | Manoharan M | Prakash TP | Puschl A | Tereshko V
