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1lar

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{{STRUCTURE_1lar| PDB=1lar | SCENE= }}
{{STRUCTURE_1lar| PDB=1lar | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP LAR'''
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===CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP LAR===
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==Overview==
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Most receptor-like protein tyrosine phosphatases (RPTPs) contain two conserved phosphatase domains (D1 and D2) in their intracellular region. The carboxy-terminal D2 domain has little or no catalytic activity. The crystal structure of the tandem D1 and D2 domains of the human RPTP LAR revealed that the tertiary structures of the LAR D1 and D2 domains are very similar to each other, with the exception of conformational differences at two amino acid positions in the D2 domain. Site-directed mutational changes at these positions (Leu-1644-to-Tyr and Glu-1779-to-Asp) conferred a robust PTPase activity to the D2 domain. The catalytic sites of both domains are accessible, in contrast to the dimeric blocked orientation model previously suggested. The relative orientation of the LAR D1 and D2 domains, constrained by a short linker, is stabilized by extensive interdomain interactions, suggesting that this orientation might be favored in solution.
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(as it appears on PubMed at http://www.pubmed.gov), where 10338209 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10338209}}
==About this Structure==
==About this Structure==
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[[Category: Lar protein]]
[[Category: Lar protein]]
[[Category: Tyrosine phosphatease]]
[[Category: Tyrosine phosphatease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:43:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:08:43 2008''

Revision as of 09:09, 2 July 2008

Image:1lar.png

Template:STRUCTURE 1lar

CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASE DOMAINS OF RPTP LAR

Template:ABSTRACT PUBMED 10338209

About this Structure

1LAR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tandem phosphatase domains of RPTP LAR., Nam HJ, Poy F, Krueger NX, Saito H, Frederick CA, Cell. 1999 May 14;97(4):449-57. PMID:10338209

Page seeded by OCA on Wed Jul 2 12:08:43 2008

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