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Ibuprofen
From Proteopedia
(Difference between revisions)
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<scene name='42/429113/Binding_site/1'>Ibuprofen binding site</scene>. | <scene name='42/429113/Binding_site/1'>Ibuprofen binding site</scene>. | ||
| - | Unlike most other NSAIDs, ibuprofen also acts as an inhibitor of Rho kinase and may be useful in recovery from spinal-cord injury.<ref name="R56">PMID:22350947</ref><ref name="R57">PMID:33197553</ref> | + | Unlike most other NSAIDs, ibuprofen also acts as an inhibitor of [[Rho kinase]] and may be useful in recovery from spinal-cord injury.<ref name="R56">PMID:22350947</ref><ref name="R57">PMID:33197553</ref> |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 12:27, 27 June 2023
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References
- ↑ Rao P, Knaus EE. Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. J Pharm Pharm Sci. 2008 Sep 20;11(2):81s-110s. PMID:19203472 doi:10.18433/j3t886
- ↑ Kakuta H, Zheng X, Oda H, Harada S, Sugimoto Y, Sasaki K, Tai A. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem. 2008 Apr 24;51(8):2400-11. PMID:18363350 doi:10.1021/jm701191z
- ↑ Kopp MA, Liebscher T, Niedeggen A, Laufer S, Brommer B, Jungehulsing GJ, Strittmatter SM, Dirnagl U, Schwab JM. Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury. Cell Tissue Res. 2012 Jul;349(1):119-32. PMID:22350947 doi:10.1007/s00441-012-1334-7
- ↑ Luo M, Li YQ, Lu YF, Wu Y, Liu R, Zheng YR, Yin M. Exploring the potential of RhoA inhibitors to improve exercise-recoverable spinal cord injury: A systematic review and meta-analysis. J Chem Neuroanat. 2021 Jan;111:101879. PMID:33197553 doi:10.1016/j.jchemneu.2020.101879
