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8jj6

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Current revision (09:13, 30 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8jj6 is ON HOLD until Paper Publication
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==Structure of the NELF-BCE complex==
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<StructureSection load='8jj6' size='340' side='right'caption='[[8jj6]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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Authors: Wang, Z., Cao, Y., Qin, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8jj6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JJ6 FirstGlance]. <br>
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Description: Structure of the NELF-BCE complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jj6 OCA], [https://pdbe.org/8jj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jj6 RCSB], [https://www.ebi.ac.uk/pdbsum/8jj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jj6 ProSAT]</span></td></tr>
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[[Category: Cao, Y]]
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</table>
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[[Category: Qin, Y]]
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== Function ==
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[[Category: Wang, Z]]
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[https://www.uniprot.org/uniprot/NELFB_HUMAN NELFB_HUMAN] Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding.<ref>PMID:10199401</ref> <ref>PMID:12612062</ref> <ref>PMID:23884411</ref> <ref>PMID:27282391</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cao Y]]
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[[Category: Qin Y]]
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[[Category: Wang Z]]

Current revision

Structure of the NELF-BCE complex

PDB ID 8jj6

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OCA

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