Mitogen-activated protein kinase kinase kinase

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	**[[2rf0]] - hMAP3K10 SH3 domain - NMR		**[[2rf0]] - hMAP3K10 SH3 domain - NMR
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-	*MAP3K12
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-	**[[8deg]] - hMAP3K12 + inhibitor<br />
	*MAP3K11		*MAP3K11
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	**[[5cen]] - hMAP3K12 <br />		**[[5cen]] - hMAP3K12 <br />
-	**[[5ceo]] - hMAP3K12 + inhibitor<br />	+	**[[5ceo]], [[8deg]] - hMAP3K12 + inhibitor<br />
	*MAP3K14 kinase domain 343-686 (NIK)		*MAP3K14 kinase domain 343-686 (NIK)

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Revision as of 07:54, 2 July 2023

spinqualitylabelsall models Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey) (PDB code 2o2v). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Mitogen-activated protein kinase kinase kinase or DLK (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of MAPK and MAP2K which are activated by phosphorylation. MAP3K activates MAP2K[1]. Disease MAP3K1 mutations are observed in various cancer types and in particular in luminal beast cancer[2].

3D Structures of Mitogen-activated protein kinase kinase kinase

Updated on 02-July-2023

References

1. ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902
2. ↑ Santen RJ, Song RX, McPherson R, Kumar R, Adam L, Jeng MH, Yue W. The role of mitogen-activated protein (MAP) kinase in breast cancer. J Steroid Biochem Mol Biol. 2002 Feb;80(2):239-56. PMID:11897507