1lea

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{{STRUCTURE_1lea| PDB=1lea | SCENE= }}
{{STRUCTURE_1lea| PDB=1lea | SCENE= }}
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'''SOLUTION STRUCTURE OF THE LEXA REPRESSOR DNA BINDING DETERMINED BY 1H NMR SPECTROSCOPY'''
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===SOLUTION STRUCTURE OF THE LEXA REPRESSOR DNA BINDING DETERMINED BY 1H NMR SPECTROSCOPY===
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==Overview==
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The structure of the 84 residue DNA binding domain of the Escherichia coli LexA repressor has been determined from NMR data using distance geometry and restrained molecular dynamics. The assignment of the 1H NMR spectrum of the molecule, derived from 2- and 3-D homonuclear experiments, is also reported. A total of 613 non-redundant distance restraints were used to give a final family of 28 structures. The structured region of the molecule consisted of residues 4-69 and yielded a r.m.s. deviation from an average of 0.9 A for backbone and 1.6 A for all heavy atoms. The structure contains three regular alpha-helices at residues 6-21 (I), 28-35 (II) and 41-52 (III), and an antiparallel beta-sheet at residues 56-58 and 66-68. Helices II and III form a variant helix-turn-helix DNA binding motif, with an unusual one residue insert at residue 38. The topology of the LexA DNA binding domain is found to be the same as for the DNA binding domains of the catabolic activator protein, human histone 5, the HNF-3/fork head protein and the Kluyveromyces lactis heat shock transcription factor.
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{{ABSTRACT_PUBMED_8076591}}
==About this Structure==
==About this Structure==
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1LEA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEA OCA].
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1LEA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEA OCA].
==Reference==
==Reference==
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[[Category: Schnarr, M.]]
[[Category: Schnarr, M.]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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Revision as of 21:12, 27 July 2008

Image:1lea.png

Template:STRUCTURE 1lea

SOLUTION STRUCTURE OF THE LEXA REPRESSOR DNA BINDING DETERMINED BY 1H NMR SPECTROSCOPY

Template:ABSTRACT PUBMED 8076591

About this Structure

1LEA is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of the LexA repressor DNA binding domain determined by 1H NMR spectroscopy., Fogh RH, Ottleben G, Ruterjans H, Schnarr M, Boelens R, Kaptein R, EMBO J. 1994 Sep 1;13(17):3936-44. PMID:8076591

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