8pkp

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m (Protected "8pkp" [edit=sysop:move=sysop])
Current revision (06:16, 19 July 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8pkp is ON HOLD
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==Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution==
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<StructureSection load='8pkp' size='340' side='right'caption='[[8pkp]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors: Hoefler, A., Yu, J., Chang, L., Zhang, Z., Yang, J., Boland, A., Barford, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8pkp]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PKP FirstGlance]. <br>
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Description: Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Boland, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pkp OCA], [https://pdbe.org/8pkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pkp RCSB], [https://www.ebi.ac.uk/pdbsum/8pkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pkp ProSAT]</span></td></tr>
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[[Category: Barford, D]]
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</table>
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[[Category: Yang, J]]
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== Function ==
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[[Category: Zhang, Z]]
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[https://www.uniprot.org/uniprot/APC1_HUMAN APC1_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref>
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[[Category: Hoefler, A]]
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== References ==
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[[Category: Chang, L]]
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<references/>
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[[Category: Yu, J]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Barford D]]
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[[Category: Boland A]]
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[[Category: Chang L]]
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[[Category: Hoefler A]]
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[[Category: Yang J]]
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[[Category: Yu J]]
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[[Category: Zhang Z]]

Current revision

Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution

PDB ID 8pkp

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