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1lew

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{{STRUCTURE_1lew| PDB=1lew | SCENE= }}
{{STRUCTURE_1lew| PDB=1lew | SCENE= }}
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'''CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A'''
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===CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A===
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==Overview==
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The structures of the MAP kinase p38 in complex with docking site peptides containing a phi(A)-X-phi(B) motif, derived from substrate MEF2A and activating enzyme MKK3b, have been solved. The peptides bind to the same site in the C-terminal domain of the kinase, which is both outside the active site and distinct from the "CD" domain previously implicated in docking site interactions. Mutational analysis on the interaction of p38 with the docking sites supports the crystallographic models and has uncovered two novel residues on the docking groove that are critical for binding. The two peptides induce similar large conformational changes local to the peptide binding groove. The peptides also induce unexpected and different conformational changes in the active site, as well as structural disorder in the phosphorylation lip.
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(as it appears on PubMed at http://www.pubmed.gov), where 12086621 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12086621}}
==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:51:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 16:13:04 2008''

Revision as of 13:15, 2 July 2008

Image:1lew.png

Template:STRUCTURE 1lew

CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A

Template:ABSTRACT PUBMED 12086621

About this Structure

1LEW is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b., Chang CI, Xu BE, Akella R, Cobb MH, Goldsmith EJ, Mol Cell. 2002 Jun;9(6):1241-9. PMID:12086621

Page seeded by OCA on Wed Jul 2 16:13:04 2008

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