1lex

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1lex.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1lex.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lex| PDB=1lex | SCENE= }}
{{STRUCTURE_1lex| PDB=1lex | SCENE= }}
-
'''STRUCTURE OF A DICATIONIC MONOIMIDAZOLE LEXITROPSIN BOUND TO DNA (ORIENTATION 1)'''
+
===STRUCTURE OF A DICATIONIC MONOIMIDAZOLE LEXITROPSIN BOUND TO DNA (ORIENTATION 1)===
-
==Overview==
+
<!--
-
An X-ray crystal structure has been solved of the complex of a dicationic lexitropsin with a B-DNA duplex of sequence CGCGAATTCGCG. The lexitropsin is identical to netropsin except for replacement of the first methylpyrrole ring by methylimidazole, converting a =CH- to =N-. Crystals are isomorphous with those of the DNA dodecamer in the absence of drug. Although the =N- for =CH- substitution was intended to make that locus on the drug molecule compatible with a G.C base pair, electrostatic attraction for the two cationic ends of the drug predominates, and this lexitropsin binds to the same central AATT site as does the parent netropsin. But unlike netropsin, this lexitropsin exhibits end-for-end disorder in the crystal. Both orientations were refined separately to completion. Final residual errors at 2.25 A resolution for the 2358 reflections above 2 sigma in F are R = 0.165 for one orientation (LexA) with 37 water molecules and 0.164 for the inverted drug orientation (LexB) with 40 water molecules. This molecular disorder is probably attributable to a weakening of binding to the AATT site occasioned by the imidazole-for-pyrrole substitution.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8527438}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8527438 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8527438}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Complexed with drug]]
[[Category: Complexed with drug]]
[[Category: Double helix]]
[[Category: Double helix]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:51:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 16:21:07 2008''

Revision as of 13:24, 2 July 2008

Template:STRUCTURE 1lex

STRUCTURE OF A DICATIONIC MONOIMIDAZOLE LEXITROPSIN BOUND TO DNA (ORIENTATION 1)

Template:ABSTRACT PUBMED 8527438

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a dicationic monoimidazole lexitropsin bound to DNA., Goodsell DS, Ng HL, Kopka ML, Lown JW, Dickerson RE, Biochemistry. 1995 Dec 26;34(51):16654-61. PMID:8527438

Page seeded by OCA on Wed Jul 2 16:21:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools