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1lfa

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{{STRUCTURE_1lfa| PDB=1lfa | SCENE= }}
{{STRUCTURE_1lfa| PDB=1lfa | SCENE= }}
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'''CD11A I-DOMAIN WITH BOUND MN++'''
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===CD11A I-DOMAIN WITH BOUND MN++===
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==Overview==
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We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion molecules 1 and 3 and can exist in both low- and high-affinity states. The metal-bound form reported here is likely to represent a high-affinity state. The CD11a I-domain structure reveals a strained hydrophobic ridge adjacent to the bound metal ion that may serve as a ligand-binding surface and is likely to rearrange in the absence of bound metal ion. The CD11a I-domain is homologous to domains found in von Willebrand factor, and mapping of mutations found in types 2a and 2b von Willebrand disease onto this structure allows consideration of the molecular basis of these forms of the disease.
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(as it appears on PubMed at http://www.pubmed.gov), where 7479767 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7479767}}
==About this Structure==
==About this Structure==
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[[Category: Qu, A.]]
[[Category: Qu, A.]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:52:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:43:48 2008''

Revision as of 06:43, 28 July 2008

Image:1lfa.png

Template:STRUCTURE 1lfa

CD11A I-DOMAIN WITH BOUND MN++

Template:ABSTRACT PUBMED 7479767

About this Structure

1LFA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin., Qu A, Leahy DJ, Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10277-81. PMID:7479767

Page seeded by OCA on Mon Jul 28 09:43:48 2008

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