1lfh

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[[Image:1lfh.jpg|left|200px]]
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{{STRUCTURE_1lfh| PDB=1lfh | SCENE= }}
{{STRUCTURE_1lfh| PDB=1lfh | SCENE= }}
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'''MOLECULAR REPLACEMENT SOLUTION OF THE STRUCTURE OF APOLACTOFERRIN, A PROTEIN DISPLAYING LARGE-SCALE CONFORMATIONAL CHANGE'''
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===MOLECULAR REPLACEMENT SOLUTION OF THE STRUCTURE OF APOLACTOFERRIN, A PROTEIN DISPLAYING LARGE-SCALE CONFORMATIONAL CHANGE===
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==Overview==
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The crystal structure of an orthorhombic form of human apolactoferrin (ApoLf) has been determined from 2.8 A diffractometer data by molecular replacement methods. A variety of search models derived from the diferric lactoferrin structure (Fe2Lf) were used to obtain a consistent solution to the rotation function. An R-factor search gave the correct translational solution and the model was refined by rigid-body least-squares refinement (program CORELS). Only three of the four domains were located correctly by this procedure, however; the fourth was finally placed correctly by rotating it manually onto three strands of electron density which were recognized as part of its central beta-sheet. The final model, refined by restrained least-squares methods to an R factor of 0.214 for data in the resolution range 10.0 to 2.8 A, shows a large domain movement in the N-terminal half of the molecule (a 54 degree rotation of domain N2) and smaller domain movements elsewhere, when compared with Fe2Lf. A feature of the crystal structure is that although the ApoLf and Fe2Lf unit cells appear very similar, their crystal packing and molecular structures are quite different.
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The line below this paragraph, {{ABSTRACT_PUBMED_1772635}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1772635 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1772635}}
==About this Structure==
==About this Structure==
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[[Category: Norris, G E.]]
[[Category: Norris, G E.]]
[[Category: Iron transport]]
[[Category: Iron transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:52:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 19:47:22 2008''

Revision as of 16:52, 2 July 2008

Image:1lfh.png

Template:STRUCTURE 1lfh

MOLECULAR REPLACEMENT SOLUTION OF THE STRUCTURE OF APOLACTOFERRIN, A PROTEIN DISPLAYING LARGE-SCALE CONFORMATIONAL CHANGE

Template:ABSTRACT PUBMED 1772635

About this Structure

1LFH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular replacement solution of the structure of apolactoferrin, a protein displaying large-scale conformational change., Norris GE, Anderson BF, Baker EN, Acta Crystallogr B. 1991 Dec 1;47 ( Pt 6):998-1004. PMID:1772635

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