1l6m
From Proteopedia
(New page: 200px<br /> <applet load="1l6m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l6m, resolution 2.40Å" /> '''Neutrophil Gelatina...) |
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| - | [[Image:1l6m. | + | [[Image:1l6m.jpg|left|200px]]<br /><applet load="1l6m" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1l6m, resolution 2.40Å" /> | caption="1l6m, resolution 2.40Å" /> | ||
'''Neutrophil Gelatinase-associated Lipocalin is a Novel Bacteriostatic Agent that Interferes with Siderophore-mediated Iron Acquisition'''<br /> | '''Neutrophil Gelatinase-associated Lipocalin is a Novel Bacteriostatic Agent that Interferes with Siderophore-mediated Iron Acquisition'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1L6M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FE, SO4, DBH and DBS as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1L6M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FE:'>FE</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=DBH:'>DBH</scene> and <scene name='pdbligand=DBS:'>DBS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6M OCA]. |
==Reference== | ==Reference== | ||
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[[Category: siderophore]] | [[Category: siderophore]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:16:45 2008'' |
Revision as of 14:16, 15 February 2008
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Neutrophil Gelatinase-associated Lipocalin is a Novel Bacteriostatic Agent that Interferes with Siderophore-mediated Iron Acquisition
Overview
First identified as a neutrophil granule component, neutrophil, gelatinase-associated lipocalin (NGAL; also called human neutrophil, lipocalin, 24p3, uterocalin, or neu-related lipocalin) is a member of the, lipocalin family of binding proteins. Putative NGAL ligands, including, neutrophil chemotactic agents such as N-formylated tripeptides, have all, been refuted by recent biochemical and structural results. NGAL has, subsequently been implicated in diverse cellular processes, but without a, characterized ligand, the molecular basis of these functions remained, mysterious. Here we report that NGAL tightly binds bacterial, catecholate-type ferric siderophores through a cyclically permuted, hybrid, electrostatic/cation-pi interaction and is a potent bacteriostatic agent, in iron-limiting conditions. We therefore propose that NGAL participates, in the antibacterial iron depletion strategy of the innate immune system.
About this Structure
1L6M is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Full crystallographic information is available from OCA.
Reference
The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition., Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, Strong RK, Mol Cell. 2002 Nov;10(5):1033-43. PMID:12453412
Page seeded by OCA on Fri Feb 15 16:16:45 2008
Categories: Homo sapiens | Single protein | Bluhm, M.E. | Borregaard, N. | Goetz, D.H. | Raymond, K.N. | Strong, R.K. | DBH | DBS | FE | SO4 | Lipocalin | Siderophore
