1lj2

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[[Image:1lj2.gif|left|200px]]
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{{STRUCTURE_1lj2| PDB=1lj2 | SCENE= }}
{{STRUCTURE_1lj2| PDB=1lj2 | SCENE= }}
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'''Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization'''
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===Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization===
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==Overview==
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Rotaviruses, segmented double-stranded RNA viruses, co-opt the eukaryotic translation machinery with the aid of nonstructural protein 3 (NSP3), a rotaviral functional homolog of the cellular poly(A) binding protein (PABP). NSP3 binds to viral mRNA 3' consensus sequences and circularizes mRNA via interactions with eIF4G. Here, we present the X-ray structure of the C-terminal domain of NSP3 (NSP3-C) recognizing a fragment of eIF4GI. Homodimerization of NSP3-C yields a symmetric, elongated, largely alpha-helical structure with two hydrophobic eIF4G binding pockets at the dimer interface. Site-directed mutagenesis and isothermal titration calorimetry documented that NSP3 and PABP use analogous eIF4G recognition strategies, despite marked differences in tertiary structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 12086624 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12086624}}
==About this Structure==
==About this Structure==
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[[Category: Rotavirus]]
[[Category: Rotavirus]]
[[Category: Translation]]
[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:58:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 20:59:58 2008''

Revision as of 17:59, 2 July 2008

Image:1lj2.png

Template:STRUCTURE 1lj2

Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization

Template:ABSTRACT PUBMED 12086624

About this Structure

1LJ2 is a Protein complex structure of sequences from Simian rotavirus a/sa11. Full crystallographic information is available from OCA.

Reference

Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization., Groft CM, Burley SK, Mol Cell. 2002 Jun;9(6):1273-83. PMID:12086624

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