1lb5
From Proteopedia
(New page: 200px<br /> <applet load="1lb5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lb5, resolution 2.40Å" /> '''TRAF6-RANK Complex'...) |
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caption="1lb5, resolution 2.40Å" /> | caption="1lb5, resolution 2.40Å" /> | ||
'''TRAF6-RANK Complex'''<br /> | '''TRAF6-RANK Complex'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LB5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1LB5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: traf6-rank complex]] | [[Category: traf6-rank complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:17:27 2008'' |
Revision as of 14:17, 15 February 2008
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TRAF6-RANK Complex
Contents |
Overview
Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the, only TRAF family member that participates in signal transduction of both, the TNF receptor (TNFR) superfamily and the interleukin-1 receptor, (IL-1R)/Toll-like receptor (TLR) superfamily; it is important for adaptive, immunity, innate immunity and bone homeostasis. Here we report crystal, structures of TRAF6, alone and in complex with TRAF6-binding peptides from, CD40 and TRANCE-R (also known as RANK), members of the TNFR superfamily, to gain insight into the mechanism by which TRAF6 mediates several, signalling cascades. A 40 degrees difference in the directions of the, bound peptides in TRAF6 and TRAF2 shows that there are marked structural, differences between receptor recognition by TRAF6 and other TRAFs. The, structural determinant of the petide TRAF6 interaction reveals a, Pro-X-Glu-X-X-(aromatic/acidic residue) TRAF6-binding motif, which is, present not only in CD40 and TRANCE-R but also in the three IRAK adapter, kinases for IL-1R/TLR signalling. Cell-permeable peptides with the, TRAF6-binding motif inhibit TRAF6 signalling, which indicates their, potential as therapeutic modulators. Our studies identify a universal, mechanism by which TRAF6 regulates several signalling cascades in adaptive, immunity, innate immunity and bone homeostasis.
Disease
Known diseases associated with this structure: Osteolysis, familial expansile OMIM:[603499], Paget disease of bone OMIM:[603499]
About this Structure
1LB5 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Distinct molecular mechanism for initiating TRAF6 signalling., Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H, Nature. 2002 Jul 25;418(6896):443-7. PMID:12140561
Page seeded by OCA on Fri Feb 15 16:17:27 2008
Categories: Homo sapiens | Protein complex | Arron, J.R. | Choi, Y. | Cirilli, M. | Darnay, B.G. | Du, K. | Dzivenu, O. | Kobayashi, T. | Lamothe, B. | Pike, J.W. | Segal, D. | Shevde, N.K. | Singh, S. | Vologodskaia, M. | Wu, H. | Ye, H. | Yim, M. | Traf6-rank complex
