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1ljm

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[[Image:1ljm.gif|left|200px]]
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[[Image:1ljm.png|left|200px]]
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{{STRUCTURE_1ljm| PDB=1ljm | SCENE= }}
{{STRUCTURE_1ljm| PDB=1ljm | SCENE= }}
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'''DNA recognition is mediated by conformational transition and by DNA bending'''
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===DNA recognition is mediated by conformational transition and by DNA bending===
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==Overview==
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The Runt domain proteins are transcription regulators of major developmental pathways. Here we present the crystal structures of the Runt domain (RD) of the human protein RUNX1 and its DNA binding site in their free states and compare them with the published crystal structures of RD bound to DNA and to the partner protein CBFbeta. We demonstrate that (1) RD undergoes an allosteric transition upon DNA binding, which is further stabilized by CBFbeta, and that (2) the free DNA target adopts a bent-helical conformation compatible with that of the complex. These findings elucidate the mechanism by which CBFbeta enhances RD binding to DNA as well as the role of the intrinsic conformation of the DNA target in the recognition process.
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The line below this paragraph, {{ABSTRACT_PUBMED_12377125}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12377125 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12377125}}
==About this Structure==
==About this Structure==
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[[Category: Beta-sandwich]]
[[Category: Beta-sandwich]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:58:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:01:29 2008''

Revision as of 18:01, 2 July 2008

Image:1ljm.png

Template:STRUCTURE 1ljm

DNA recognition is mediated by conformational transition and by DNA bending

Template:ABSTRACT PUBMED 12377125

About this Structure

1LJM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending., Bartfeld D, Shimon L, Couture GC, Rabinovich D, Frolow F, Levanon D, Groner Y, Shakked Z, Structure. 2002 Oct;10(10):1395-407. PMID:12377125

Page seeded by OCA on Wed Jul 2 21:01:29 2008

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