This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1lk2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1lk2.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1lk2.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lk2| PDB=1lk2 | SCENE= }}
{{STRUCTURE_1lk2| PDB=1lk2 | SCENE= }}
-
'''1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide'''
+
===1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide===
-
==Overview==
+
<!--
-
We identify and consider some characteristics of a peptide antagonist for the Ag-specific receptor on 2C cells (the 2C TCR). The peptide, GNYSFYAL (called GNY), binds to H-2K(b), and a very high-resolution crystal structure of the GNY-K(b) complex at 1.35 A is described. Although the GNY peptide does not bind to L(d), the potency of GNY-K(b) as an antagonist is evident from its ability to specifically inhibit 2C TCR-mediated reactions to an allogenic agonist complex (QLSPFPFDL-L(d)), as well as to a syngeneic agonist complex (SIYRYYGL-K(b)). The crystal structure and the activities of alanine-substituted peptide variants point to the properties of the peptide P4 side chain and the conformation of the Tyr-P6 side chain as the structural determinants of GNYSFYAL antagonist activity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14978103}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14978103 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14978103}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Class i mhc-peptide complex]]
[[Category: Class i mhc-peptide complex]]
[[Category: High resolution]]
[[Category: High resolution]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:59:38 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:16:37 2008''

Revision as of 18:16, 2 July 2008

Image:1lk2.png

Template:STRUCTURE 1lk2

1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide

Template:ABSTRACT PUBMED 14978103

About this Structure

1LK2 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects., Rudolph MG, Shen LQ, Lamontagne SA, Luz JG, Delaney JR, Ge Q, Cho BK, Palliser D, McKinley CA, Chen J, Wilson IA, Eisen HN, J Immunol. 2004 Mar 1;172(5):2994-3002. PMID:14978103

Page seeded by OCA on Wed Jul 2 21:16:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lk2"
Personal tools