8prx

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-	'''Unreleased structure'''
-	The entry 8prx is ON HOLD	+	==Crystal structure of human cathepsin L after reaction with the bound ketoamide inhibitor 13b==
-		+	<StructureSection load='8prx' size='340' side='right'caption='[[8prx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-	Authors: Falke, S., Lieske, J., Guenther, S., Reinke, P.Y.A., Ewert, W., Loboda, J., Karnicar, K., Usenik, A., Lindic, N., Sekirnik, A., Chapman, H.N., Hinrichs, W., Turk, D., Meents, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8prx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PRX FirstGlance]. <br>
-	Description: Crystal structure of human cathepsin L after reaction with the bound ketoamide inhibitor 13b	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-	[[Category: Unreleased Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KH0:~{tert}-butyl+~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{S})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate'>KH0</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	[[Category: Hinrichs, W]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8prx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8prx OCA], [https://pdbe.org/8prx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8prx RCSB], [https://www.ebi.ac.uk/pdbsum/8prx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8prx ProSAT]</span></td></tr>
-	[[Category: Sekirnik, A]]	+	</table>
-	[[Category: Ewert, W]]	+	== Function ==
-	[[Category: Chapman, H.N]]	+	[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
-	[[Category: Lindic, N]]	+	__TOC__
-	[[Category: Karnicar, K]]	+	</StructureSection>
-	[[Category: Loboda, J]]	+	[[Category: Homo sapiens]]
-	[[Category: Lieske, J]]	+	[[Category: Large Structures]]
-	[[Category: Usenik, A]]	+	[[Category: Chapman HN]]
-	[[Category: Meents, A]]	+	[[Category: Ewert W]]
-	[[Category: Turk, D]]	+	[[Category: Falke S]]
-	[[Category: Falke, S]]	+	[[Category: Guenther S]]
-	[[Category: Guenther, S]]	+	[[Category: Hinrichs W]]
-	[[Category: Reinke, P.Y.A]]	+	[[Category: Karnicar K]]
		+	[[Category: Lieske J]]
		+	[[Category: Lindic N]]
		+	[[Category: Loboda J]]
		+	[[Category: Meents A]]
		+	[[Category: Reinke PYA]]
		+	[[Category: Sekirnik A]]
		+	[[Category: Turk D]]
		+	[[Category: Usenik A]]

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Revision as of 05:55, 23 August 2023

Crystal structure of human cathepsin L after reaction with the bound ketoamide inhibitor 13b

spinqualitylabelsall models PDB ID 8prx Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Structural highlights 8prx is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.8Å Ligands: , , , , , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CATL1_HUMAN Important for the overall degradation of proteins in lysosomes. Contents 1 Structural highlights 2 Function