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1ll5

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[[Image:1ll5.gif|left|200px]]
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{{STRUCTURE_1ll5| PDB=1ll5 | SCENE= }}
{{STRUCTURE_1ll5| PDB=1ll5 | SCENE= }}
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'''X-ray crystal structure of AmpC WT beta-lactamase in complex with covalently bound imipenem'''
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===X-ray crystal structure of AmpC WT beta-lactamase in complex with covalently bound imipenem===
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==Overview==
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To determine how imipenem inhibits the class C beta-lactamase AmpC, the X-ray crystal structure of the acyl-enzyme complex was determined to a resolution of 1.80 A. In the complex, the lactam carbonyl oxygen of imipenem has flipped by approximately 180 degrees compared to its expected position; the electrophilic acyl center is thus displaced from the point of hydrolytic attack. This conformation resembles that of imipenem bound to the class A enzyme TEM-1 but is different from that of moxalactam bound to AmpC.
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(as it appears on PubMed at http://www.pubmed.gov), where 12435704 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12435704}}
==About this Structure==
==About this Structure==
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[[Category: Carbapenem]]
[[Category: Carbapenem]]
[[Category: Imipenem]]
[[Category: Imipenem]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:01:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:21:41 2008''

Revision as of 18:21, 2 July 2008

Image:1ll5.png

Template:STRUCTURE 1ll5

X-ray crystal structure of AmpC WT beta-lactamase in complex with covalently bound imipenem

Template:ABSTRACT PUBMED 12435704

About this Structure

1LL5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for imipenem inhibition of class C beta-lactamases., Beadle BM, Shoichet BK, Antimicrob Agents Chemother. 2002 Dec;46(12):3978-80. PMID:12435704

Page seeded by OCA on Wed Jul 2 21:21:41 2008

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