1llo

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[[Image:1llo.gif|left|200px]]
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{{Seed}}
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[[Image:1llo.png|left|200px]]
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{{STRUCTURE_1llo| PDB=1llo | SCENE= }}
{{STRUCTURE_1llo| PDB=1llo | SCENE= }}
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'''HEVAMINE A (A PLANT ENDOCHITINASE/LYSOZYME) COMPLEXED WITH ALLOSAMIDIN'''
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===HEVAMINE A (A PLANT ENDOCHITINASE/LYSOZYME) COMPLEXED WITH ALLOSAMIDIN===
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==Overview==
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The plant enzyme hevamine has both chitinase and lysozyme activity. HPLC analysis of the products of the hydrolysis of chitopentaose shows that hevamine acts with retention of the configuration, despite the absence of a nucleophilic or stabilizing carboxylate. To analyze the stabilization of a putative oxocarbonium ion intermediate, the X-ray structure of hevamine complexed with the inhibitor allosamidin was determined at 1.85 A resolution. This structure supports the role of Glu127 as a proton donor. The allosamizoline group binds in the center of the active site, mimicking a reaction intermediate in which a positive charge at C1 is stabilized intramolecularly by the carbonyl oxygen of the N-acetyl group at C2.
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(as it appears on PubMed at http://www.pubmed.gov), where 7495789 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7495789}}
==About this Structure==
==About this Structure==
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[[Category: Chitinase]]
[[Category: Chitinase]]
[[Category: Lysozyme]]
[[Category: Lysozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:02:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:23:09 2008''

Revision as of 18:23, 2 July 2008

Image:1llo.png

Template:STRUCTURE 1llo

HEVAMINE A (A PLANT ENDOCHITINASE/LYSOZYME) COMPLEXED WITH ALLOSAMIDIN

Template:ABSTRACT PUBMED 7495789

About this Structure

1LLO is a Single protein structure of sequence from Hevea brasiliensis. Full crystallographic information is available from OCA.

Reference

Stereochemistry of chitin hydrolysis by a plant chitinase/lysozyme and X-ray structure of a complex with allosamidin: evidence for substrate assisted catalysis., Terwisscha van Scheltinga AC, Armand S, Kalk KH, Isogai A, Henrissat B, Dijkstra BW, Biochemistry. 1995 Dec 5;34(48):15619-23. PMID:7495789

Page seeded by OCA on Wed Jul 2 21:23:09 2008

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