1lmc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1lmc.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1lmc.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lmc| PDB=1lmc | SCENE= }}
{{STRUCTURE_1lmc| PDB=1lmc | SCENE= }}
-
'''THE CRYSTAL STRUCTURE OF A COMPLEX BETWEEN BULGECIN, A BACTERIAL METABOLITE, AND LYSOZYME FROM THE RAINBOW TROUT'''
+
===THE CRYSTAL STRUCTURE OF A COMPLEX BETWEEN BULGECIN, A BACTERIAL METABOLITE, AND LYSOZYME FROM THE RAINBOW TROUT===
-
==Overview==
+
<!--
-
Bulgecin, a sulfonated glycopeptide produced by Pseudomonas acidophila and Pseudomonas mesoacidophila, induces bulge formation and enhances lysis of bacterial cell walls when used in combination with beta-lactam antibiotics. The compound does not itself exhibit any antibacterial activity, but has been shown to inhibit a soluble lytic transglycosylase (SLT70) from Escherichia coli which has a lysozyme-like domain. Recently, the crystal structure of an SLT-bulgecin complex has been determined to 3.5 A resolution. We report here the crystal structure of a complex between lysozyme from the rainbow trout (RBTL) and bulgecin A at 2.0 A resolution. As for the SLT-bulgecin complex, bulgecin is bound with the glycosaminyl moiety in subsite C and the proline residue in site D of the active-site cleft of RBTL, where it makes hydrogen-bonding interactions with the catalytic residues. The taurine moiety is bound to the left side of subsites E and F in the lower part of the active-site cleft. From the observed position of the bulgecin molecule, it seems reasonable that it is an inhibitor of rainbow trout lysozyme. The lysozymes may, in general, be a target for the design of a novel type of antibiotics distinct from the beta-lactams which are insensitive to the muramidases.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15299732}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15299732 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15299732}}
==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Hough, E.]]
[[Category: Hough, E.]]
[[Category: Karlsen, S.]]
[[Category: Karlsen, S.]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:03:46 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:25:21 2008''

Revision as of 18:25, 2 July 2008

Image:1lmc.png

Template:STRUCTURE 1lmc

THE CRYSTAL STRUCTURE OF A COMPLEX BETWEEN BULGECIN, A BACTERIAL METABOLITE, AND LYSOZYME FROM THE RAINBOW TROUT

Template:ABSTRACT PUBMED 15299732

About this Structure

1LMC is a Single protein structure of sequence from Oncorhynchus mykiss. Full crystallographic information is available from OCA.

Reference

Structure of a complex between bulgecin, a bacterial metabolite, and lysozyme from the rainbow trout., Karlsen S, Hough E, Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):115-23. PMID:15299732

Page seeded by OCA on Wed Jul 2 21:25:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lmc"
Personal tools