1lmz

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[[Image:1lmz.gif|left|200px]]
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{{Seed}}
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[[Image:1lmz.png|left|200px]]
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{{STRUCTURE_1lmz| PDB=1lmz | SCENE= }}
{{STRUCTURE_1lmz| PDB=1lmz | SCENE= }}
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'''Solution Structure of 3-Methyladenine DNA Glycosylase I (TAG)'''
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===Solution Structure of 3-Methyladenine DNA Glycosylase I (TAG)===
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==Overview==
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The Escherichia coli enzyme 3-methyladenine DNA glycosylase I (TAG) hydrolyzes the glycosidic bond of 3-methyladenine (3-MeA) in DNA and is found in many bacteria and some higher eukaryotes. TAG shows little primary sequence identity with members of the well-known helix-hairpin-helix (HhH) superfamily of DNA repair glycosylases, which consists of AlkA, EndoIII, MutY and hOGG1. Unexpectedly, the three-dimensional solution structure reported here reveals TAG as member of this superfamily. The restricted specificity of TAG for 3-MeA bases probably arises from its unique aromatic rich 3-MeA binding pocket and the absence of a catalytic aspartate that is present in all other HhH family members.
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The line below this paragraph, {{ABSTRACT_PUBMED_12161745}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12161745 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12161745}}
==About this Structure==
==About this Structure==
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1LMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMZ OCA].
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1LMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMZ OCA].
==Reference==
==Reference==
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[[Category: Solution structure]]
[[Category: Solution structure]]
[[Category: Tag]]
[[Category: Tag]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:04:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:27:47 2008''

Revision as of 18:27, 2 July 2008

Image:1lmz.png

Template:STRUCTURE 1lmz

Solution Structure of 3-Methyladenine DNA Glycosylase I (TAG)

Template:ABSTRACT PUBMED 12161745

About this Structure

1LMZ is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

3-Methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member., Drohat AC, Kwon K, Krosky DJ, Stivers JT, Nat Struct Biol. 2002 Sep;9(9):659-64. PMID:12161745

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