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1lot

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{{STRUCTURE_1lot| PDB=1lot | SCENE= }}
{{STRUCTURE_1lot| PDB=1lot | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE COMPLEX OF ACTIN WITH VITAMIN D-BINDING PROTEIN'''
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===CRYSTAL STRUCTURE OF THE COMPLEX OF ACTIN WITH VITAMIN D-BINDING PROTEIN===
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==Overview==
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A high-affinity complex formed between G-actin and plasma vitamin D-binding protein (DBP) is believed to form part of a scavenging system in the plasma for removing actin released from damaged cells. In the study presented here, we describe the crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution. The complex contains one molecule of each protein bound together by extensive ionic, polar, and hydrophobic interactions. It includes an ATP and a calcium ion bound to actin, but no evidence of vitamin D metabolites bound to the DBP. Both actin and DBP are multidomain molecules, two major domains in actin and three in DBP. All of these domains contribute to the interaction between the molecules. DBP enfolds the end of the actin molecule, principally in actin subdomain 3 but with additional interactions in actin subdomain 1. This orientation is similar to the binding of profilin to actin, as predicted from previous studies. The more extensive interactions of DBP give an affinity for actin some 3 orders of magnitude higher than that for profilin. The larger "footprint" of DBP on actin also leads to an overlap with the actin-binding site of gelsolin domain I.
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(as it appears on PubMed at http://www.pubmed.gov), where 12119014 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12119014}}
==About this Structure==
==About this Structure==
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[[Category: Structural protein]]
[[Category: Structural protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:07:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:38:10 2008''

Revision as of 18:38, 2 July 2008

Image:1lot.png

Template:STRUCTURE 1lot

CRYSTAL STRUCTURE OF THE COMPLEX OF ACTIN WITH VITAMIN D-BINDING PROTEIN

Template:ABSTRACT PUBMED 12119014

About this Structure

1LOT is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution., Head JF, Swamy N, Ray R, Biochemistry. 2002 Jul 23;41(29):9015-20. PMID:12119014

Page seeded by OCA on Wed Jul 2 21:38:10 2008

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