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Cytochrome P450

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Line 18: Line 18:
*[[Montelukast]] - anti rhinitis
*[[Montelukast]] - anti rhinitis
*[[Noxafil]] - antifungal drug which binds to CYP51.
*[[Noxafil]] - antifungal drug which binds to CYP51.
 +
*[[Cobicistat]] - anti HIV/AIDS drug which binds to CYP3A4.
== Structural highlights ==
== Structural highlights ==

Revision as of 10:37, 16 January 2024

Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry 1og5)

Drag the structure with the mouse to rotate

References

  1. ↑ Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. PMID:12369887
  2. ↑ Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225 doi:http://dx.doi.org/10.1038/nature01862

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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