This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1lq8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1lq8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1lq8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lq8| PDB=1lq8 | SCENE= }}
{{STRUCTURE_1lq8| PDB=1lq8 | SCENE= }}
-
'''Crystal structure of cleaved protein C inhibitor'''
+
===Crystal structure of cleaved protein C inhibitor===
-
==Overview==
+
<!--
-
Protein C inhibitor (PCI) is a member of the serpin family that has many biological functions. In blood it acts as a procoagulant, and, in the seminal vesicles, it is required for spermatogenesis. The activity of PCI is affected by heparin binding in a manner unique among the heparin binding serpins, and, in addition, PCI binds hydrophobic hormones with apparent specificity for retinoids. Here we present the 2.4 A crystallographic structure of reactive center loop (RCL) cleaved PCI. A striking feature of the structure is a two-turn N-terminal shortening of helix A, which creates a large hydrophobic pocket that docking studies indicate to be the retinoid binding site. On the basis of surface electrostatic properties, a novel mechanism for heparin activation is proposed.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12575940}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12575940 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12575940}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Retinoic acid]]
[[Category: Retinoic acid]]
[[Category: Serpin]]
[[Category: Serpin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:10:07 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:46:45 2008''

Revision as of 18:46, 2 July 2008

Image:1lq8.png

Template:STRUCTURE 1lq8

Crystal structure of cleaved protein C inhibitor

Template:ABSTRACT PUBMED 12575940

About this Structure

1LQ8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation., Huntington JA, Kjellberg M, Stenflo J, Structure. 2003 Feb;11(2):205-15. PMID:12575940

Page seeded by OCA on Wed Jul 2 21:46:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lq8"
Personal tools