8pww

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m (Protected "8pww" [edit=sysop:move=sysop])
Current revision (05:18, 5 June 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8pww is ON HOLD until Paper Publication
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==PfRH5 bound to monoclonal antibody MAD8-151==
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<StructureSection load='8pww' size='340' side='right'caption='[[8pww]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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Authors: Farrell, B., Higgins, M.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8pww]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PWW FirstGlance]. <br>
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Description: PfRH5 bound to monoclonal antibody MAD8-151
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.945&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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[[Category: Higgins, M.K]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pww OCA], [https://pdbe.org/8pww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pww RCSB], [https://www.ebi.ac.uk/pdbsum/8pww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pww ProSAT]</span></td></tr>
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[[Category: Farrell, B]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RH5_PLAF7 RH5_PLAF7] Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:18827878, PubMed:19000690, PubMed:22080952, PubMed:25296023, PubMed:25583518, PubMed:27374406, PubMed:28186186, PubMed:28409866, PubMed:31204103). By binding P113 at the surface of the merozoite and human BSG/basigin on the erythrocyte membrane, leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes (PubMed:22080952, PubMed:25296023, PubMed:25583518, PubMed:27374406, PubMed:28186186). In addition, the interaction with BSG results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:27374406, PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866).<ref>PMID:18827878</ref> <ref>PMID:19000690</ref> <ref>PMID:22080952</ref> <ref>PMID:25296023</ref> <ref>PMID:25583518</ref> <ref>PMID:27374406</ref> <ref>PMID:28186186</ref> <ref>PMID:28409866</ref> <ref>PMID:31204103</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Farrell B]]
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[[Category: Higgins MK]]

Current revision

PfRH5 bound to monoclonal antibody MAD8-151

PDB ID 8pww

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