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1lrh

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[[Image:1lrh.gif|left|200px]]
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{{STRUCTURE_1lrh| PDB=1lrh | SCENE= }}
{{STRUCTURE_1lrh| PDB=1lrh | SCENE= }}
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'''Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid'''
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===Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid===
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==Overview==
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The structure of auxin-binding protein 1 (ABP1) from maize has been determined at 1.9 A resolution, revealing its auxin-binding site. The structure confirms that ABP1 belongs to the ancient and functionally diverse germin/seed storage 7S protein superfamily. The binding pocket of ABP1 is predominantly hydrophobic with a metal ion deep inside the pocket coordinated by three histidines and a glutamate. Auxin binds within this pocket, with its carboxylate binding the zinc and its aromatic ring binding hydrophobic residues including Trp151. There is a single disulfide between Cys2 and Cys155. No conformational rearrangement of ABP1 was observed when auxin bound to the protein in the crystal, but examination of the structure reveals a possible mechanism of signal transduction.
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The line below this paragraph, {{ABSTRACT_PUBMED_12065401}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12065401 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12065401}}
==About this Structure==
==About this Structure==
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[[Category: Double stranded parallel beta helix]]
[[Category: Double stranded parallel beta helix]]
[[Category: Germin like protein]]
[[Category: Germin like protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:12:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:52:26 2008''

Revision as of 18:52, 2 July 2008

Image:1lrh.png

Template:STRUCTURE 1lrh

Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid

Template:ABSTRACT PUBMED 12065401

About this Structure

1LRH is a Single protein structure of sequence from Zea mays. Full crystallographic information is available from OCA.

Reference

Crystal structure of auxin-binding protein 1 in complex with auxin., Woo EJ, Marshall J, Bauly J, Chen JG, Venis M, Napier RM, Pickersgill RW, EMBO J. 2002 Jun 17;21(12):2877-85. PMID:12065401

Page seeded by OCA on Wed Jul 2 21:52:26 2008

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