8chb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Inward-facing conformation of the ABC transporter BmrA C436S/A582C cross-linked mutant== | |
| - | + | <StructureSection load='8chb' size='340' side='right'caption='[[8chb]], [[Resolution|resolution]] 3.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8chb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CHB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.14Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8chb OCA], [https://pdbe.org/8chb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8chb RCSB], [https://www.ebi.ac.uk/pdbsum/8chb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8chb ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BMRA_BACSU BMRA_BACSU] An efflux transporter able to transport Hoechst 33342, ethidium bromide, doxorubicin and a number of other drugs in vitro into inside out vesicles. The endogenous substrate is unknown. It has been suggested that NBD dimerization induced by ATP-binding causes a large conformational change responsible for substrate translocation (PubMed:18215075). Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).<ref>PMID:18215075</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus subtilis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Di Cesare M]] | ||
| + | [[Category: Hanssen E]] | ||
| + | [[Category: Jault JM]] | ||
| + | [[Category: Kaplan E]] | ||
| + | [[Category: Orelle C]] | ||
| + | [[Category: Valimehr S]] | ||
Revision as of 10:00, 20 December 2023
Inward-facing conformation of the ABC transporter BmrA C436S/A582C cross-linked mutant
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