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1lte

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[[Image:1lte.gif|left|200px]]
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{{Seed}}
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[[Image:1lte.png|left|200px]]
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{{STRUCTURE_1lte| PDB=1lte | SCENE= }}
{{STRUCTURE_1lte| PDB=1lte | SCENE= }}
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'''STRUCTURE OF A LEGUME LECTIN WITH AN ORDERED N-LINKED CARBOHYDRATE IN COMPLEX WITH LACTOSE'''
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===STRUCTURE OF A LEGUME LECTIN WITH AN ORDERED N-LINKED CARBOHYDRATE IN COMPLEX WITH LACTOSE===
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==Overview==
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The three-dimensional structure of the lactose complex of the Erythrina corallodendron lectin (EcorL), a dimer of N-glycosylated subunits, was determined crystallographically and refined at 2.0 angstrom resolution to an R value of 0.19. The tertiary structure of the subunit is similar to that of other legume lectins, but interference by the bulky N-linked heptasaccharide, which is exceptionally well ordered in the crystal, forces the EcorL dimer into a drastically different quaternary structure. Only the galactose moiety of the lactose ligand resides within the combining site. The galactose moiety is oriented differently from ligands in the mannose-glucose specific legume lectins and is held by hydrophobic interactions with Ala88, Tyr106, Phe131, and Ala218 and by seven hydrogen bonds, four of which are to the conserved Asp89, Asn133, and NH of Gly107. The specificity of legume lectins toward the different C-4 epimers appears to be associated with extensive variations in the outline of the variable parts of the binding sites.
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The line below this paragraph, {{ABSTRACT_PUBMED_1948067}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1948067 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1948067}}
==About this Structure==
==About this Structure==
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[[Category: Sharon, N.]]
[[Category: Sharon, N.]]
[[Category: Lectin]]
[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:16:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:10:16 2008''

Revision as of 19:10, 2 July 2008

Image:1lte.png

Template:STRUCTURE 1lte

STRUCTURE OF A LEGUME LECTIN WITH AN ORDERED N-LINKED CARBOHYDRATE IN COMPLEX WITH LACTOSE

Template:ABSTRACT PUBMED 1948067

About this Structure

1LTE is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structure of a legume lectin with an ordered N-linked carbohydrate in complex with lactose., Shaanan B, Lis H, Sharon N, Science. 1991 Nov 8;254(5033):862-6. PMID:1948067

Page seeded by OCA on Wed Jul 2 22:10:16 2008

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