1lti

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[[Image:1lti.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1lti| PDB=1lti | SCENE= }}
{{STRUCTURE_1lti| PDB=1lti | SCENE= }}
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'''HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN'''
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===HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN===
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==Overview==
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Heat-labile enterotoxin (LT) is part of the cholera toxin (CT) family and consists of a catalytic A subunit and a B pentamer that serves to recognize the oligosaccharide part of the GM1 ganglioside receptor. We report here the crystal structure of heat-labile enterotoxin in complex with the disaccharide portion of the Thomsen-Friedenreich (T-antigen) tumor marker. The toxin:carbohydrate complex is determined to 2.13 A resolution, yielding an R-factor of 18.5%. The T-antigen disaccharide, D-Gal-beta 1,3-GalNAc-Ser/Thr, is present in more than 85% of human carcinomas and monitoring its autoimmune response is used for the early detection of tumors. Insight into the molecular recognition of this tumor antigen by sugar binding proteins can benefit the development of a diagnostic tool for human carcinomas as well as a T-antigen directed anticancer drug delivery system.
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The line below this paragraph, {{ABSTRACT_PUBMED_8762150}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8762150 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8762150}}
==About this Structure==
==About this Structure==
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[[Category: Adp-ribosyl transferase]]
[[Category: Adp-ribosyl transferase]]
[[Category: Enterotoxin]]
[[Category: Enterotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:16:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:11:14 2008''

Revision as of 19:11, 2 July 2008

Image:1lti.png

Template:STRUCTURE 1lti

HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN

Template:ABSTRACT PUBMED 8762150

About this Structure

1LTI is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli., van den Akker F, Steensma E, Hol WG, Protein Sci. 1996 Jun;5(6):1184-8. PMID:8762150

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