1ltl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ltl.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ltl.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ltl| PDB=1ltl | SCENE= }}
{{STRUCTURE_1ltl| PDB=1ltl | SCENE= }}
-
'''THE DODECAMER STRUCTURE OF MCM FROM ARCHAEAL M. THERMOAUTOTROPHICUM'''
+
===THE DODECAMER STRUCTURE OF MCM FROM ARCHAEAL M. THERMOAUTOTROPHICUM===
-
==Overview==
+
<!--
-
Eukaryotic chromosomal DNA is licensed for replication precisely once in each cell cycle. The mini-chromosome maintenance (MCM) complex plays a role in this replication licensing. We have determined the structure of a fragment of MCM from Methanobacterium thermoautotrophicum (mtMCM), a model system for eukaryotic MCM. The structure reveals a novel dodecameric architecture with a remarkably long central channel. The channel surface has an unusually high positive charge and binds DNA. We also show that the structure of the N-terminal fragment is conserved for all MCMs proteins despite highly divergent sequences, suggesting a common architecture for a similar task: gripping/remodeling DNA and regulating MCM activity. An mtMCM mutant protein equivalent to a yeast MCM5 (CDC46) protein with the bob1 mutation at its N terminus has only subtle structural changes, suggesting a Cdc7-bypass mechanism by Bob1 in yeast. Yeast bypass experiments using MCM5 mutant proteins support the hypothesis for the bypass mechanism.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12548282}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12548282 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12548282}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Sclafani, R A.]]
[[Category: Sclafani, R A.]]
[[Category: Replication]]
[[Category: Replication]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:16:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:11:38 2008''

Revision as of 19:11, 2 July 2008

Image:1ltl.png

Template:STRUCTURE 1ltl

THE DODECAMER STRUCTURE OF MCM FROM ARCHAEAL M. THERMOAUTOTROPHICUM

Template:ABSTRACT PUBMED 12548282

About this Structure

1LTL is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

The structure and function of MCM from archaeal M. Thermoautotrophicum., Fletcher RJ, Bishop BE, Leon RP, Sclafani RA, Ogata CM, Chen XS, Nat Struct Biol. 2003 Mar;10(3):160-7. PMID:12548282

Page seeded by OCA on Wed Jul 2 22:11:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ltl"
Personal tools