1lua

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{{STRUCTURE_1lua| PDB=1lua | SCENE= }}
{{STRUCTURE_1lua| PDB=1lua | SCENE= }}
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'''Structure of methylene-tetrahydromethanopterin dehydrogenase from Methylobacterium extorquens AM1 complexed with NADP'''
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===Structure of methylene-tetrahydromethanopterin dehydrogenase from Methylobacterium extorquens AM1 complexed with NADP===
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==Overview==
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NADP-dependent methylene-H(4)MPT dehydrogenase, MtdA, from Methylobacterium extorquens AM1 catalyzes the dehydrogenation of methylene-tetrahydromethanopterin and methylene-tetrahydrofolate with NADP(+) as cosubstrate. The X-ray structure of MtdA with and without NADP bound was established at 1.9 A resolution. The enzyme is present as a homotrimer. The alpha,beta fold of the monomer is related to that of methylene-H(4)F dehydrogenases, suggesting a common evolutionary origin. The position of the active site is located within a large crevice built up by the two domains of one subunit and one domain of a second subunit. Methylene-H(4)MPT could be modeled into the cleft, and crucial active site residues such as Phe18, Lys256, His260, and Thr102 were identified. The molecular basis of the different substrate specificities and different catalytic demands of MtdA compared to methylene-H(4)F dehydrogenases are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_12176390}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12176390 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12176390}}
==About this Structure==
==About this Structure==
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[[Category: Warkentin, E.]]
[[Category: Warkentin, E.]]
[[Category: Alpha/beta twisted open sheet structure]]
[[Category: Alpha/beta twisted open sheet structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:17:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:15:32 2008''

Revision as of 19:15, 2 July 2008

Image:1lua.png

Template:STRUCTURE 1lua

Structure of methylene-tetrahydromethanopterin dehydrogenase from Methylobacterium extorquens AM1 complexed with NADP

Template:ABSTRACT PUBMED 12176390

About this Structure

1LUA is a Single protein structure of sequence from Methylobacterium extorquens. Full crystallographic information is available from OCA.

Reference

Structure of methylene-tetrahydromethanopterin dehydrogenase from methylobacterium extorquens AM1., Ermler U, Hagemeier CH, Roth A, Demmer U, Grabarse W, Warkentin E, Vorholt JA, Structure. 2002 Aug;10(8):1127-37. PMID:12176390

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