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1luz

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{{STRUCTURE_1luz| PDB=1luz | SCENE= }}
{{STRUCTURE_1luz| PDB=1luz | SCENE= }}
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'''Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)'''
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===Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)===
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==Overview==
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The vaccinia virus protein K3L subverts the mammalian antiviral defense mechanism by inhibiting the RNA-dependent protein kinase PKR. K3L is a structural mimic of PKR's natural substrate, the translation initiation factor eIF2alpha. To further our understanding of K3L inhibitory function and PKR substrate recognition, we have solved the 1.8 A X-ray crystal structure of K3L. The structure consists of a five-strand beta barrel with an intervening helix insert region similar in topology to the functionally divergent S1 domain. Mutational analysis identifies two proximal regions of the K3L structure as possessing specialized PKR binding and inhibitory function. Further analysis reveals that PKR dimerization composes a key switch that regulates both its catalytic activation and its molecular recognition of K3L and eIF2alpha.
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(as it appears on PubMed at http://www.pubmed.gov), where 12191475 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12191475}}
==About this Structure==
==About this Structure==
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[[Category: Sicheri, F.]]
[[Category: Sicheri, F.]]
[[Category: 5 stranded anti-parallel beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:21:48 2008''

Revision as of 19:21, 2 July 2008

Image:1luz.png

Template:STRUCTURE 1luz

Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)

Template:ABSTRACT PUBMED 12191475

About this Structure

1LUZ is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition., Dar AC, Sicheri F, Mol Cell. 2002 Aug;10(2):295-305. PMID:12191475

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