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1lv1

From Proteopedia

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{{STRUCTURE_1lv1| PDB=1lv1 | SCENE= }}
{{STRUCTURE_1lv1| PDB=1lv1 | SCENE= }}
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'''Crystal Structure Analysis of the non-active site mutant of tethered HIV-1 protease to 2.1A resolution'''
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===Crystal Structure Analysis of the non-active site mutant of tethered HIV-1 protease to 2.1A resolution===
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==Overview==
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Autolysis rates of the C95M and C95M/C1095A mutants of a HIV-1 protease tethered dimer have been determined by real time NMR and it is observed that the double mutant has approximately two times higher rate. X-ray structure of the C95M/C1095A double mutant has been solved and refined to 2.1 A resolution. Comparison of the double mutant structure with that of C95M single mutant reveals that there is a shift in the position of the catalytic aspartates and the bound catalytic water. The mutation also causes a loss of hydrophobic packing near the dimerization domain of the protein. These observations demonstrate that subtle changes are adequate to cause significant changes in the rate of autolysis of the double mutant. This provides a rationale for the effects of remote mutations on the activity and drug resistance of the enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 12051725 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12051725}}
==About this Structure==
==About this Structure==
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[[Category: Mittal, R.]]
[[Category: Mittal, R.]]
[[Category: Beta-ribbon flap]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:19:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:23:22 2008''

Revision as of 19:23, 2 July 2008

Image:1lv1.png

Template:STRUCTURE 1lv1

Crystal Structure Analysis of the non-active site mutant of tethered HIV-1 protease to 2.1A resolution

Template:ABSTRACT PUBMED 12051725

About this Structure

1LV1 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Effects of remote mutation on the autolysis of HIV-1 PR: X-ray and NMR investigations., Kumar M, Kannan KK, Hosur MV, Bhavesh NS, Chatterjee A, Mittal R, Hosur RV, Biochem Biophys Res Commun. 2002 Jun 7;294(2):395-401. PMID:12051725

Page seeded by OCA on Wed Jul 2 22:23:22 2008

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