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1lv0

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{{STRUCTURE_1lv0| PDB=1lv0 | SCENE= }}
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'''Crystal structure of the Rab effector guanine nucleotide dissociation inhibitor (GDI) in complex with a geranylgeranyl (GG) peptide'''
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===Crystal structure of the Rab effector guanine nucleotide dissociation inhibitor (GDI) in complex with a geranylgeranyl (GG) peptide===
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==Overview==
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Rab GTPases, key regulators of membrane targeting and fusion, require the covalent attachment of geranylgeranyl lipids to their C terminus for function. To elucidate the role of lipid in Rab recycling, we have determined the crystal structure of Rab guanine nucleotide dissociation inhibitor (alphaGDI) in complex with a geranylgeranyl (GG) ligand (H(2)N-Cys-(S-GG)-OMe). The lipid is bound beneath the Rab binding platform in a shallow hydrophobic groove. Mutation of the binding pocket in the brain-specific alphaGDI leads to mental retardation. Strikingly, lipid binding acts through a conserved allosteric switching mechanism to promote release of the GDI-Rab[GDP] complex from the membrane.
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(as it appears on PubMed at http://www.pubmed.gov), where 12623022 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12623022}}
==About this Structure==
==About this Structure==
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[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Protein-ligand complex]]
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Revision as of 19:23, 2 July 2008

Image:1lv0.png

Template:STRUCTURE 1lv0

Crystal structure of the Rab effector guanine nucleotide dissociation inhibitor (GDI) in complex with a geranylgeranyl (GG) peptide

Template:ABSTRACT PUBMED 12623022

About this Structure

1LV0 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Geranylgeranyl switching regulates GDI-Rab GTPase recycling., An Y, Shao Y, Alory C, Matteson J, Sakisaka T, Chen W, Gibbs RA, Wilson IA, Balch WE, Structure. 2003 Mar;11(3):347-57. PMID:12623022

Page seeded by OCA on Wed Jul 2 22:23:02 2008

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