1lv7

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{{STRUCTURE_1lv7| PDB=1lv7 | SCENE= }}
{{STRUCTURE_1lv7| PDB=1lv7 | SCENE= }}
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'''Crystal Structure of the AAA domain of FtsH'''
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===Crystal Structure of the AAA domain of FtsH===
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==Overview==
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Eubacteria and eukaryotic cellular organelles have membrane-bound ATP-dependent proteases, which degrade misassembled membrane protein complexes and play a vital role in membrane quality control. The bacterial protease FtsH also degrades an interesting subset of cytoplasmic regulatory proteins, including sigma(32), LpxC, and lambda CII. The crystal structure of the ATPase module of FtsH has been solved, revealing an alpha/beta nucleotide binding domain connected to a four-helix bundle, similar to the AAA modules of proteins involved in DNA replication and membrane fusion. A sulfate anion in the ATP binding pocket mimics the beta-phosphate group of an adenine nucleotide. A hexamer form of FtsH has been modeled, providing insights into possible modes of nucleotide binding and intersubunit catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 12176385 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12176385}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta domain]]
[[Category: Alpha/beta domain]]
[[Category: Four helix bundle]]
[[Category: Four helix bundle]]
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Revision as of 19:24, 2 July 2008

Template:STRUCTURE 1lv7

Crystal Structure of the AAA domain of FtsH

Template:ABSTRACT PUBMED 12176385

About this Structure

1LV7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution., Krzywda S, Brzozowski AM, Verma C, Karata K, Ogura T, Wilkinson AJ, Structure. 2002 Aug;10(8):1073-83. PMID:12176385

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