1lvn

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[[Image:1lvn.gif|left|200px]]
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{{STRUCTURE_1lvn| PDB=1lvn | SCENE= }}
{{STRUCTURE_1lvn| PDB=1lvn | SCENE= }}
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'''CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE'''
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===CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE===
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==Overview==
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The X-ray crystal structure of the copper-containing quinoprotein amine oxidase from E. coli has been determined in complex with the antidepressant drug tranylcypromine to 2.4 A resolution. The drug is a racemic mix of two enantiomers, but only one is seen bound to the enzyme. The other enantiomer is not acting as a substrate for the enzyme as no catalytic activity was detected when the enzyme was initially exposed to the drug. The inhibition of human copper amine oxidases could be a source of side-effects in its use as an antidepressant to inhibit the flavin-containing monoamine oxidases in the brain.
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(as it appears on PubMed at http://www.pubmed.gov), where 15498552 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15498552}}
==About this Structure==
==About this Structure==
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[[Category: Wilmot, C M.]]
[[Category: Wilmot, C M.]]
[[Category: Inhibitor complex]]
[[Category: Inhibitor complex]]
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Revision as of 19:30, 2 July 2008

Image:1lvn.png

Template:STRUCTURE 1lvn

CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE

Template:ABSTRACT PUBMED 15498552

About this Structure

1LVN is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine., Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE, FEBS Lett. 2004 Oct 22;576(3):301-5. PMID:15498552

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