1lw6

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{{STRUCTURE_1lw6| PDB=1lw6 | SCENE= }}
{{STRUCTURE_1lw6| PDB=1lw6 | SCENE= }}
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'''Crystal Structure of the Complex of Subtilisin BPN' with Chymotrypsin Inhibitor 2 at 1.5 Angstrom Resolution'''
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===Crystal Structure of the Complex of Subtilisin BPN' with Chymotrypsin Inhibitor 2 at 1.5 Angstrom Resolution===
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==Overview==
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A classical peptide inhibitor of serine proteases that is hydrolyzed approximately 10(7) times more slowly than a good substrate is shown to form an acyl-enzyme intermediate rapidly. Despite this quick first step, further reaction is slowed dramatically because of tight and oriented binding of the cleaved peptide, preventing acyl-enzyme hydrolysis and favoring the reverse reaction. Moreover, this mechanism appears to be common to a large class of tight-binding serine protease inhibitors that mimic good substrates. The arrest of enzymatic reaction at the intermediate stage allowed us to determine that the consensus nucleophilic attack angle is close to 90 degrees in the reactive Michaelis complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 12142461 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12142461}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:21:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:36:52 2008''

Revision as of 19:37, 2 July 2008

Image:1lw6.png

Template:STRUCTURE 1lw6

Crystal Structure of the Complex of Subtilisin BPN' with Chymotrypsin Inhibitor 2 at 1.5 Angstrom Resolution

Template:ABSTRACT PUBMED 12142461

About this Structure

1LW6 is a Protein complex structure of sequences from Bacillus amyloliquefaciens and Hordeum vulgare. Full crystallographic information is available from OCA.

Reference

A clogged gutter mechanism for protease inhibitors., Radisky ES, Koshland DE Jr, Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10316-21. Epub 2002 Jul 25. PMID:12142461

Page seeded by OCA on Wed Jul 2 22:36:52 2008

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