1lsl
From Proteopedia
(New page: 200px<br /> <applet load="1lsl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lsl, resolution 1.90Å" /> '''Crystal Structure o...) |
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caption="1lsl, resolution 1.90Å" /> | caption="1lsl, resolution 1.90Å" /> | ||
'''Crystal Structure of the Thrombospondin-1 Type 1 Repeats'''<br /> | '''Crystal Structure of the Thrombospondin-1 Type 1 Repeats'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LSL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FUL and FUC as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1LSL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FUL:'>FUL</scene> and <scene name='pdbligand=FUC:'>FUC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LSL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tsr]] | [[Category: tsr]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:20:06 2008'' |
Revision as of 14:20, 15 February 2008
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Crystal Structure of the Thrombospondin-1 Type 1 Repeats
Contents |
Overview
Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which, mediate cell attachment, glycosaminoglycan binding, inhibition of, angiogenesis, activation of TGFbeta, and inhibition of matrix, metalloproteinases. The crystal structure of the TSRs reported in this, article reveals a novel, antiparallel, three-stranded fold that consists, of alternating stacked layers of tryptophan and arginine residues from, respective strands, capped by disulfide bonds on each end. The front face, of the TSR contains a right-handed spiral, positively charged groove that, might be the "recognition" face, mediating interactions with various, ligands. This is the first high-resolution crystal structure of a TSR, domain that provides a prototypic architecture for structural and, functional exploration of the diverse members of the TSR superfamily.
Disease
Known disease associated with this structure: Sudden infant death with dysgenesis of the testes syndrome OMIM:[604714]
About this Structure
1LSL is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication., Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH, J Cell Biol. 2002 Oct 28;159(2):373-82. Epub 2002 Oct 21. PMID:12391027
Page seeded by OCA on Fri Feb 15 16:20:06 2008
Categories: Homo sapiens | Single protein | Dong, Y. | Duquette, M. | Joachimiak, A. | Lawler, J. | Liu, J. | Tan, K. | Wang, J.H. | Zhang, R. | FUC | FUL | Tsp-1 | Tsr
