1oee

From Proteopedia

Revision as of 09:39, 30 October 2007

YODA FROM ESCHERICHIA COLI CRYSTALLISED WITH CADMIUM IONS

Overview

We have determined the crystal structure of YodA, an Escherichia coli, protein of unknown function. YodA had been identified under conditions of, cadmium stress, and we confirm that it binds metals such as cadmium and, zinc. We have also found nickel bound in one of the crystal forms. YodA is, composed of two domains: a main lipocalin/calycin-like domain and a, helical domain. The principal metal-binding site lies on one side of the, calycin domain, thus making YodA the first metal-binding lipocalin known., Our experiments suggest that YodA expression may be part of a more general, stress response. From sequence analogy with the C-terminal domain of a, metal-binding receptor of a member of bacterial ATP-binding cassette, transporters, we propose a three-dimensional model for this receptor ... [(full description)]

About this Structure

1OEE is a [Single protein] structure of sequence from [Escherichia coli] with CD as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

YodA from Escherichia coli is a metal-binding, lipocalin-like protein., David G, Blondeau K, Schiltz M, Penel S, Lewit-Bentley A, J Biol Chem. 2003 Oct 31;278(44):43728-35. Epub 2003 Aug 8. PMID:12909634

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