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1lxi

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[[Image:1lxi.gif|left|200px]]
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{{STRUCTURE_1lxi| PDB=1lxi | SCENE= }}
{{STRUCTURE_1lxi| PDB=1lxi | SCENE= }}
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'''Refinement of BMP7 crystal structure'''
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===Refinement of BMP7 crystal structure===
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==Overview==
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Activins and bone morphogenetic proteins (BMPs) elicit diverse biological responses by signaling through two pairs of structurally related type I and type II receptors. Here we report the crystal structure of BMP7 in complex with the extracellular domain (ECD) of the activin type II receptor. Our structure produces a compelling four-receptor model, revealing that the types I and II receptor ECDs make no direct contacts. Nevertheless, we find that truncated receptors lacking their cytoplasmic domain retain the ability to cooperatively assemble in the cell membrane. Also, the affinity of BMP7 for its low-affinity type I receptor ECD increases 5-fold in the presence of its type II receptor ECD. Taken together, our results provide a view of the ligand-mediated cooperative assembly of BMP and activin receptors that does not rely on receptor-receptor contacts.
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(as it appears on PubMed at http://www.pubmed.gov), where 12667445 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12667445}}
==About this Structure==
==About this Structure==
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[[Category: Kwiatkowski, W.]]
[[Category: Kwiatkowski, W.]]
[[Category: Cystine-knot growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:23:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:46:10 2008''

Revision as of 19:46, 2 July 2008

Image:1lxi.png

Template:STRUCTURE 1lxi

Refinement of BMP7 crystal structure

Template:ABSTRACT PUBMED 12667445

About this Structure

1LXI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly., Greenwald J, Groppe J, Gray P, Wiater E, Kwiatkowski W, Vale W, Choe S, Mol Cell. 2003 Mar;11(3):605-17. PMID:12667445

Page seeded by OCA on Wed Jul 2 22:46:10 2008

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