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1y0q
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0q OCA], [https://pdbe.org/1y0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0q RCSB], [https://www.ebi.ac.uk/pdbsum/1y0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0q ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0q OCA], [https://pdbe.org/1y0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0q RCSB], [https://www.ebi.ac.uk/pdbsum/1y0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Group I introns are catalytic RNAs capable of orchestrating two sequential phosphotransesterification reactions that result in self-splicing. To understand how the group I intron active site facilitates catalysis, we have solved the structure of an active ribozyme derived from the orf142-I2 intron from phage Twort bound to a four-nucleotide product RNA at a resolution of 3.6 A. In addition to the three conserved domains characteristic of all group I introns, the Twort ribozyme has peripheral insertions characteristic of phage introns. These elements form a ring that completely envelops the active site, where a snug pocket for guanosine is formed by a series of stacked base triples. The structure of the active site reveals three potential binding sites for catalytic metals, and invokes a role for the 2' hydroxyl of the guanosine substrate in organization of the active site for catalysis. | ||
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| - | Crystal structure of a phage Twort group I ribozyme-product complex.,Golden BL, Kim H, Chase E Nat Struct Mol Biol. 2005 Jan;12(1):82-9. Epub 2004 Dec 5. PMID:15580277<ref>PMID:15580277</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1y0q" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Ribozyme 3D structures|Ribozyme 3D structures]] | *[[Ribozyme 3D structures|Ribozyme 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of an active group I ribozyme-product complex
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