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1ly1

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{{STRUCTURE_1ly1| PDB=1ly1 | SCENE= }}
{{STRUCTURE_1ly1| PDB=1ly1 | SCENE= }}
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'''Structure and Mechanism of T4 Polynucleotide Kinase'''
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===Structure and Mechanism of T4 Polynucleotide Kinase===
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==Overview==
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T4 polynucleotide kinase (Pnk), in addition to being an invaluable research tool, exemplifies a family of bifunctional enzymes with 5'-kinase and 3'-phosphatase activities that play key roles in RNA and DNA repair. T4 Pnk is a homotetramer composed of a C-terminal phosphatase domain and an N-terminal kinase domain. The 2.0 A crystal structure of the isolated kinase domain highlights a tunnel-like active site through the heart of the enzyme, with an entrance on the 5' OH acceptor side that can accommodate a single-stranded polynucleotide. The active site is composed of essential side chains that coordinate the beta phosphate of the NTP donor and the 3' phosphate of the 5' OH acceptor, plus a putative general acid that activates the 5' OH. The structure rationalizes the different specificities of T4 and eukaryotic Pnk and suggests a model for the assembly of the tetramer.
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(as it appears on PubMed at http://www.pubmed.gov), where 12110598 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12110598}}
==About this Structure==
==About this Structure==
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[[Category: Polynucleotide]]
[[Category: Polynucleotide]]
[[Category: T4]]
[[Category: T4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:24:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:47:40 2008''

Revision as of 19:47, 2 July 2008

Image:1ly1.png

Template:STRUCTURE 1ly1

Structure and Mechanism of T4 Polynucleotide Kinase

Template:ABSTRACT PUBMED 12110598

About this Structure

1LY1 is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme., Wang LK, Lima CD, Shuman S, EMBO J. 2002 Jul 15;21(14):3873-80. PMID:12110598

Page seeded by OCA on Wed Jul 2 22:47:40 2008

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