8jzm
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210== |
| - | + | <StructureSection load='8jzm' size='340' side='right'caption='[[8jzm]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8jzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JZM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jzm OCA], [https://pdbe.org/8jzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jzm RCSB], [https://www.ebi.ac.uk/pdbsum/8jzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jzm ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Jia | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref> |
| - | [[Category: Mobli | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Jia X]] | ||
| + | [[Category: Kobe B]] | ||
| + | [[Category: Maxwell MJ]] | ||
| + | [[Category: Mobli M]] | ||
| + | [[Category: Rahaman MH]] | ||
Current revision
The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210
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Categories: Homo sapiens | Large Structures | Jia X | Kobe B | Maxwell MJ | Mobli M | Rahaman MH
