1lyy
From Proteopedia
(New page: 200px<br /> <applet load="1lyy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lyy, resolution 1.8Å" /> '''AMYLOIDOGENIC VARIAN...) |
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caption="1lyy, resolution 1.8Å" /> | caption="1lyy, resolution 1.8Å" /> | ||
'''AMYLOIDOGENIC VARIANT (ASP67HIS) OF HUMAN LYSOZYME'''<br /> | '''AMYLOIDOGENIC VARIANT (ASP67HIS) OF HUMAN LYSOZYME'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LYY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Full crystallographic information is available from [http:// | + | 1LYY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LYY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
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Revision as of 14:21, 15 February 2008
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AMYLOIDOGENIC VARIANT (ASP67HIS) OF HUMAN LYSOZYME
Contents |
Overview
Tissue deposition of soluble proteins as amyloid fibrils underlies a range, of fatal diseases. The two naturally occurring human lysozyme variants are, both amyloidogenic, and are shown here to be unstable. They aggregate to, form amyloid fibrils with transformation of the mainly helical native, fold, observed in crystal structures, to the amyloid fibril cross-beta, fold. Biophysical studies suggest that partly folded intermediates are, involved in fibrillogenesis, and this may be relevant to amyloidosis, generally.
Disease
Known diseases associated with this structure: Amyloidosis, renal OMIM:[153450], Microphthalmia, syndromic 1 OMIM:[309800]
About this Structure
1LYY is a Single protein structure of sequence from Homo sapiens. Active as Lysozyme, with EC number 3.2.1.17 Full crystallographic information is available from OCA.
Reference
Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis., Booth DR, Sunde M, Bellotti V, Robinson CV, Hutchinson WL, Fraser PE, Hawkins PN, Dobson CM, Radford SE, Blake CC, Pepys MB, Nature. 1997 Feb 27;385(6619):787-93. PMID:9039909
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