1m2v

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[[Image:1m2v.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1m2v| PDB=1m2v | SCENE= }}
{{STRUCTURE_1m2v| PDB=1m2v | SCENE= }}
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'''Crystal Structure of the yeast Sec23/24 heterodimer'''
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===Crystal Structure of the yeast Sec23/24 heterodimer===
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==Overview==
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COPII-coated vesicles form on the endoplasmic reticulum by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and Sec13/31 to induce coat polymerization and membrane deformation. Crystallographic analysis of the Saccharomyces cerevisiae Sec23/24-Sar1 complex reveals a bow-tie-shaped structure, 15 nm long, with a membrane-proximal surface that is concave and positively charged to conform to the size and acidic-phospholipid composition of the COPII vesicle. Sec23 and Sar1 form a continuous surface stabilized by a non-hydrolysable GTP analogue, and Sar1 has rearranged from the GDP conformation to expose amino-terminal residues that will probably embed in the bilayer. The GTPase-activating protein (GAP) activity of Sec23 involves an arginine side chain inserted into the Sar1 active site. These observations establish the structural basis for GTP-dependent recruitment of a vesicular coat complex, and for uncoating through coat-controlled GTP hydrolysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 12239560 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12239560}}
==About this Structure==
==About this Structure==
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[[Category: Vwa domain]]
[[Category: Vwa domain]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:34:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:06:00 2008''

Revision as of 20:06, 2 July 2008

Image:1m2v.png

Template:STRUCTURE 1m2v

Crystal Structure of the yeast Sec23/24 heterodimer

Template:ABSTRACT PUBMED 12239560

About this Structure

1M2V is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat., Bi X, Corpina RA, Goldberg J, Nature. 2002 Sep 19;419(6904):271-7. PMID:12239560

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