1m2z

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[[Image:1m2z.gif|left|200px]]
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{{Seed}}
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[[Image:1m2z.png|left|200px]]
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{{STRUCTURE_1m2z| PDB=1m2z | SCENE= }}
{{STRUCTURE_1m2z| PDB=1m2z | SCENE= }}
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'''Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif'''
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===Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif===
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==Overview==
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Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermediary factor 2. Despite structural similarity to other steroid receptors, the GR LBD adopts a surprising dimer configuration involving formation of an intermolecular beta sheet. Functional studies demonstrate that the novel dimer interface is important for GR-mediated activation. The structure also reveals an additional charge clamp that determines the binding selectivity of a coactivator and a distinct ligand binding pocket that explains its selectivity for endogenous steroid hormones. These results establish a framework for understanding the roles of protein-hormone and protein-protein interactions in GR signaling pathways.
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The line below this paragraph, {{ABSTRACT_PUBMED_12151000}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12151000 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12151000}}
==About this Structure==
==About this Structure==
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[[Category: Hormone binding pocket]]
[[Category: Hormone binding pocket]]
[[Category: Tif2]]
[[Category: Tif2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:34:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:06:24 2008''

Revision as of 20:06, 2 July 2008

Image:1m2z.png

Template:STRUCTURE 1m2z

Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif

Template:ABSTRACT PUBMED 12151000

About this Structure

1M2Z is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition., Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE, Cell. 2002 Jul 12;110(1):93-105. PMID:12151000

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