1m3g

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{{STRUCTURE_1m3g| PDB=1m3g | SCENE= }}
{{STRUCTURE_1m3g| PDB=1m3g | SCENE= }}
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'''SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF MAPK PHOSPHATASE PAC-1: INSIGHTS INTO SUBSTRATE-INDUCED ENZYMATIC ACTIVATION'''
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===SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF MAPK PHOSPHATASE PAC-1: INSIGHTS INTO SUBSTRATE-INDUCED ENZYMATIC ACTIVATION===
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==Overview==
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Inactivation of mitogen-activated protein kinases (MAPKs) by MAPK phosphatases (MKPs) is accomplished via substrate-induced activation of the latter enzymes; however, the structural basis for the underlying mechanism remains elusive. Here, we report the three-dimensional solution structure of the C-terminal phosphatase domain of the prototypical MKP PAC-1, determined when bound to phosphate. Structural and biochemical analyses reveal unique active site geometry of the enzyme important for binding to phosphorylated threonine and tyrosine of MAPK ERK2. Our study further demonstrates that the dynamic interaction between the N-terminal kinase binding domain and the C-terminal phosphatase domain of an MKP is directly coupled to MAPK-induced conformational change of the phosphatase active site, which is essential for eliciting its full enzymatic activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_12575935}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12575935}}
==About this Structure==
==About this Structure==
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1M3G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ikz 1ikz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M3G OCA].
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1M3G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ikz 1ikz]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M3G OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Pac-1]]
[[Category: Pac-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:35:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:08:14 2008''

Revision as of 20:08, 2 July 2008

Image:1m3g.png

Template:STRUCTURE 1m3g

SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF MAPK PHOSPHATASE PAC-1: INSIGHTS INTO SUBSTRATE-INDUCED ENZYMATIC ACTIVATION

Template:ABSTRACT PUBMED 12575935

About this Structure

1M3G is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1ikz. Full experimental information is available from OCA.

Reference

Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP., Farooq A, Plotnikova O, Chaturvedi G, Yan S, Zeng L, Zhang Q, Zhou MM, Structure. 2003 Feb;11(2):155-64. PMID:12575935

Page seeded by OCA on Wed Jul 2 23:08:14 2008

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