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1m46

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[[Image:1m46.gif|left|200px]]
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{{STRUCTURE_1m46| PDB=1m46 | SCENE= }}
{{STRUCTURE_1m46| PDB=1m46 | SCENE= }}
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'''CRYSTAL STRUCTURE OF MLC1P BOUND TO IQ4 OF MYO2P, A CLASS V MYOSIN'''
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===CRYSTAL STRUCTURE OF MLC1P BOUND TO IQ4 OF MYO2P, A CLASS V MYOSIN===
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==Overview==
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IQ motifs are widespread in nature. Mlc1p is a calmodulin-like myosin light chain that binds to IQ motifs of a class V myosin, Myo2p, and an IQGAP-related protein, Iqg1p, playing a role in polarized growth and cytokinesis in Saccharomyces cerevisiae. The crystal structures of Mlc1p bound to IQ2 and IQ4 of Myo2p differ dramatically. When bound to IQ2, Mlc1p adopts a compact conformation in which both the N- and C-lobes interact with the IQ motif. However, in the complex with IQ4, the N-lobe no longer interacts with the IQ motif, resulting in an extended conformation of Mlc1p. The two light chain structures relate to two distinct subfamilies of IQ motifs, one of which does not interact with the N-lobes of calmodulin-like light chains. The correlation between light chain structure and IQ sequence is demonstrated further by sedimentation velocity analysis of complexes of Mlc1p with IQ motifs from Myo2p and Iqg1p. The resulting 'free' N-lobes of myosin light chains in the extended conformation could mediate the formation of ternary complexes during protein localization and/or partner recruitment.
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(as it appears on PubMed at http://www.pubmed.gov), where 12554638 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12554638}}
==About this Structure==
==About this Structure==
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[[Category: Myosin light chain]]
[[Category: Myosin light chain]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:36:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:10:08 2008''

Revision as of 20:10, 2 July 2008

Image:1m46.png

Template:STRUCTURE 1m46

CRYSTAL STRUCTURE OF MLC1P BOUND TO IQ4 OF MYO2P, A CLASS V MYOSIN

Template:ABSTRACT PUBMED 12554638

About this Structure

1M46 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications., Terrak M, Wu G, Stafford WF, Lu RC, Dominguez R, EMBO J. 2003 Feb 3;22(3):362-71. PMID:12554638

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