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1m4m

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{{STRUCTURE_1m4m| PDB=1m4m | SCENE= }}
{{STRUCTURE_1m4m| PDB=1m4m | SCENE= }}
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'''Mouse Survivin'''
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===Mouse Survivin===
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==Overview==
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The coupling of apoptosis (programmed cell death) to the cell division cycle is essential for homeostasis and genomic integrity. Here, we report the crystal structure of survivin, an inhibitor of apoptosis, which has been implicated in both control of cell death and regulation of cell division. In addition to a conserved N-terminal Zn finger baculovirus IAP repeat, survivin forms a dimer through a symmetric interaction with an intermolecularly bound Zn atom located along the molecular dyad axis. The interaction of the dimer-related C-terminal alpha helices forms an extended surface of approximately 70 A in length. Mutagenesis analysis revealed that survivin dimerization and an extended negatively charged surface surrounding Asp-71 are required to counteract apoptosis and preserve ploidy. These findings may provide a structural basis for a dual role of survivin in inhibition of apoptosis and regulation of cell division.
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(as it appears on PubMed at http://www.pubmed.gov), where 10949038 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10949038}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
[[Category: Zn finger baculovirus iap repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:37:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:12:02 2008''

Revision as of 20:12, 2 July 2008

Image:1m4m.png

Template:STRUCTURE 1m4m

Mouse Survivin

Template:ABSTRACT PUBMED 10949038

About this Structure

1M4M is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin., Muchmore SW, Chen J, Jakob C, Zakula D, Matayoshi ED, Wu W, Zhang H, Li F, Ng SC, Altieri DC, Mol Cell. 2000 Jul;6(1):173-82. PMID:10949038

Page seeded by OCA on Wed Jul 2 23:12:02 2008

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